No investigations directly compare the impact of radiation therapy after resection and reconstruction, limiting the statements that can be made about whether radiation therapy can improve outcomes in the setting of residual disease or when there is an increased risk of tumor recurrence. However, given that radiation therapy of the femur is generally well-tolerated and residual/recurrent tumor of the femur can remain/become symptomatic, the potential benefits may be felt to outweigh the harms in select patients.
Treatment of Metastatic Carcinoma and Myeloma of the Femur
Joint MSTS/ASTRO/ASCO Guideline
Rationale